In absence of complicating medical diseases of pregnancy in antenatal women with intrauterine growth restriction, plasma homocysteine levels were estimated. Objective was to find out hyperhomocysteinemia in clinical IUGR and to compare with non-IUGR. One hundred IUGR women between 36 to 40 weeks of pregnancy and another 100 non-IUGR women in same antenatal period were selected from out patient department of C.R. Gardi Hospital, Ujjain, India. Plasma homocysteine level was estimated. Clinical criteria for IUGR was fundal height less than tenth percentile at 36 weeks, fundal height less than 30 centimeters and Abdominal circumference/Femur length ratio less than four. Neonatal weight and morbidity was recorded. Mean value of homocysteine in non-IUGR group was 7.64µmol/L while it was 13.81µmol/L in IUGR subjects. Poor dietary habits and homocysteine values show no statistically significant difference (p>0.05). Homocysteine levels in Low birth weight was 14.67µmol/L while in normal birth weight subjects it was 7.59µmol/L, with significant difference of p<0.05. IUGR in third trimester has higher homocysteine levels. Clinical intrauterine growth restriction subjects have significant hyperhomocysteinaemia, which is correlated to low birth weight in neonate (p=0.00).
Loading....